Benjamin Merlin Gaub
Project Leader and Clinical Trial Manager

Gaub

Benjamin M. Gaub joined Wyss Zurich in April 2019 as a project lead and clinical trial manager for Somagenetix. Somagenetix is harnessing the power of gene and cell therapy to treat patients with a life-threatening inborn immunodeficiency of phagocytes. Benjamin is responsible for coordinating efforts to establish i) the non-clinical safety and efficacy of mouse models ii) a GMP production process in connection with the Regenerative Medicine Platform at Wyss Zurich, and iii) an international multicenter phase I/II clinical trial. Benjamin received a B.Sc. in Chemistry from LMU Munich in 2008, completed his PhD in Neurobiology at UC Berkeley in 2015 and then joined ETH Zurich for a 3-year postdoctoral fellowship in Biophysics. During his academic training, Benjamin acquired valuable skills in gene therapy, leadership and entrepreneurship that he can now apply in his position as project lead in an effort to develop cutting-edge medical technology at Wyss Zurich.

Contact:
benjamin.gaub@wysszurich.ch
Tel. +41 44 635 7688


Vasilios Dabouras
Chief Regulatory Affairs Officer

Dabouras

Vasilios Dabouras joined Wyss Zurich in October 2019 as Chief Regulatory Affairs Officer for Somagenetix. Somagenetix is harnessing the power of gene and cell therapy to treat patients with a life-threatening inborn immunodeficiency of phagocytes. Vasilios is responsible for regulatory aspects of the development of medicinal products, health authority interactions and the registration of planned clinical trials. Vasilios completed his PhD at the Institute of Pharmaceutical Sciences at ETH Zurich before moving to industry. Vasilios has over 10 years of experience in regulatory affairs in the pharmaceutical Industry and at the European Medicines Agency. During this time, Vasilios gained experience in the regulation of the development and postmarketing of chemical and biotechnological products, plasma-derived products and ATMPs.

Contact:
vasilios.dabouras@wysszurich.ch
Tel. +41 44 635 7681


Simon Mathis
GMP Technician

Mathis

Simon Mathis joined Wyss Zurich in November 2019 as a GMP technician for Somagenetix. Somagenetix is harnessing the power of gene and cell therapy to treat patients with a life-threatening inborn immunodeficiency of phagocytes. As part of the production team, Simon will focus mainly on the establishment of a GMP production process in collaboration with the Regenerative Medicine Platform at Wyss Zurich, as well as on the non-clinical safety and efficacy of mouse models. Simon received a B.Sc. in Biotechnology from Zurich University of Applied Sciences (ZHAW) in Wädenswil in 2019. During his studies, he acquired extensive knowledge and developed valuable skills that he can now apply in his current position at Wyss Zurich.

Contact:
simon.mathis@wysszurich.ch
+41 44 634 89 39


Oleksandr Pastukhov
Technical Project Manager and Non-Clinical Lead

Pastukhov

Oleksandr Pastukhov joined Wyss Zurich in February 2020 as a Technical Project Manager and a Non-Clinical Lead for Somagenetix. Having pharmaceutical background, hands-on experience in gene therapy technologies, and in working in regulated environment, Oleksandr is responsible for development of a GMP-compliant manufacturing process and a GLP-compliant non-clinical testing of gene therapy medicinal products. Oleksandr received his diploma in clinical pharmacy from the National University of Pharmacy (Kharkiv, Ukraine) in 2006, where he then worked as a Research Associate conducting non-clinical testing of drug-candidates for pharmaceutical companies. Oleksandr completed his PhD in Biomedical Sciences at the Institute of Pharmacology (University of Bern) in 2015. The same year, he joined the University Children’s Hospital Zurich, and later the Institute for Regenerative Medicine (University of Zurich), where he worked as a Research Scientist on conventional and gene therapies for patients with inborn immune disorders.

Contact:
oleksandr.pastukhov@wysszurich.ch
Tel. +41 44 634 89 39


Ulrich Siler
Mentor Somagenetix

Siler

Ulrich Siler, Dr. rer. nat., biochemist, is the scientific laboratory head for gene therapy at the Institute for Regenerative Medicine (IREM) of the University of Zurich (UZH). Prior to entering academia in 2004, he worked in the pharmaceutical industry as a postdoctoral researcher. Since 2016 he has been an adjunct professor of Pediatric Immunology, Experimental Immunology and Gene Therapy at UZH. At University Children’s Hospital Zurich, he played a pivotal role, in collaboration with Prof. Janine Reichenbach and colleagues, in running the first successful clinical phase I/II gene therapy trial in 2005, aimed at curing patients with Chronic Granulomatous Disease. He developed a novel gene therapy system for the treatment of immunodeficiency, which will be translated into clinical practice as part of the Wyss Zurich Somagenetix project. Ulrich Siler serves as a mentor for the Somagenetix project.