It is well known that the liver has the ability to regenerate. Liver resection (surgical removal of the diseased part of the liver) for the treatment of liver cancer has been carried out for a few decades, but many tumors are inoperable, notably because the removal of a too large piece of liver is fatal.

The Wyss Zurich project will develop a novel therapeutic strategy for liver regeneration consisting of: i) surgical resection of a small healthy piece of the liver from the patient; ii) growth of this piece outside of the body in a perfusion machine until a sufficient size is reached; iii) retransplantation of the regenerated liver to the original patient while removing the remaining diseased part. Current perfusion systems are not able to keep a liver alive outside of the body for a sufficient time to allow growth and regeneration to occur. The challenging aim of the project is to extend the viability of liver tissue outside of the body up to five days and allow its growth. To this end, a perfusion machine will be developed, which will provide necessary nutrients and oxygen supply, and be equipped to monitor growth, as well as assess the functional capacity of the liver.