The currently available treatments entail various complications and provide only short-term relief. Tissue engineering using autologous cells, which offers a feasible alternative for functional restoration of the damaged urinary sphincter muscle, represents an ideal treatment option that could reverse the underlying pathologic conditions.
MUS.I.C. is seeking to translate basic knowledge of Regenerative Medicine (RM) and stem cell therapy into clinical practice by undertaking a first-in-man study using autologous muscle precursor cells (MPCs), combined with neuromuscular electromagnetic stimulation (NMES), in 40 female patients. The project's aim is to perform the tasks required to show the safety and efficacy of the proposed novel multilevel treatment and to demonstrate the reproducibility of the therapeutic effect. Additional objectives are the optimization of the advanced-therapy medicinal product (ATMP), in order to achieve totally xeno-free and facilitated manufacturing, as well as the introduction of a novel injection technique for more efficient and precise implantation of the final product.
This project is supported by EU Horizon 2020 and Wyss Zurich.
Learn more about MUS.I.C. on the Website www.music2020.ch
PROJECT PARTNERS in the EU Horizon 2020 are:
Scinus Cell Expansion TM
Collagen Solutions
University of Tübingen
Paracelsus Medical University
