The HeartOne project was originally part of the Zurich Heart, a research initiative of Hochschulmedizin Zürich that aims at revolutionizing VAD technologies based on a variety of novel approaches. In 2015, the Heart One project was spun off into Wyss Zurich.

Raffael Amacher
Project Leader - Scientist


Raffael Amacher received his Master’s degree in Mechanical Engineering (strong focus on automatic control) from ETH Zurich in 2010. In 2014 he received his doctoral degree from ETH Zurich for his research related to the control of ventricular assist devices, which he conducted at the Institute for Dynamic Systems and Control of ETH Zurich. His current focus is on translating research findings to clinical use in the field of mechanical circulatory support. Raffael Amacher is responsible for the further development, integration and validation of physiological control solutions for blood pumps.

Simone Bottan
Project Co-Leader - Product Engineer


Simone Bottan is responsible for the development of anti-fibrotic solutions applicable to Ventricular Assist Devices for the project. Simone Bottan received his M.Sc. in Biomedical Engineering from the Polytechnic University of Milan in 2008 and his Ph.D. from the Department of Mechanical and Process Engineering of ETH Zurich in 2012. Awarded Pioneer Fellow by the Innovation and Entrepreneurship Lab of ETH Zurich, Simone Bottan integrated his academic R&D expertise into Product and Business Development activities related to Medical Devices. He co-founded the ETH Zurich spin-off HYLOMORPH AG and was awarded the venture leaders USA 2015 prize. His professional mission statement is “to establish cutting edge technologies in the MedTech fields with high impact on social and healthcare systems, supported by strong ethics”.

Florian Lösch
Business Developer


Florian Lösch holds  a Ph.D. from the Institute of Robotics at ETH Zurich (2002) and an Executive MBA from the University of St. Gallen (2006). His professional experience comprises consulting (McKinsey & Co.), board memberships, and more than 12 years of management experience as Head of Development, COO, and finally CEO at MECOS AG (early Spin-Off from ETH Zurich founded in 1988 and successfully sold to MAN Diesel & Turbo in 2012). Within the HeartOne Project, Florian Lösch's role ranges from business development and support in strategic decision-taking, to negotiation support and coaching.

Barbara Röhrnbauer
Product Engineer


Barbara Röhrnbauer is responsible for mechanical integrity and mechanical biocompatibility aspects of the ventricular assist devices. Notably, her work includes finding innovative solutions for the pump design and physiological integration within the living body, in vivo testing and validation. Barbara Röhrnbauer graduated from Technische Universitaet Muenchen in 2006 with a “Diplom” in Mechanical Engineering. In 2013 she received her Ph.D. from ETH Zurich for her research on the mechanical biocompatibility of prosthetic meshes at the Center of Mechanics of ETH Zurich (Prof. E. Mazza). Until 2015 she worked in the Mechanical Integrity Department at Sulzer Pumps in Winterthur. Barbara Röhrnbauer has specific expertise in mechanics of biomedical materials and implants, animal and clinical studies, and pump design.